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doi:10.1016/j.biocel.2012.08.016, PMID: 22939972 Zeevalk GD, Manzino L, Sonsalla PK, Bernard LP (2007) Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinsons disease

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Given that an average rat weighing 200 g drinks approximately 4050 ml/day [120], it would consume 3645 mg of NAC daily, corresponding to 180225 mg/kg/day