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This leads to abnormal tau hyperphosphorylation, promoting neurofibrillary tangle (NFT) formation, which disrupts neuronal cytoskeletal integrity and axonal transport (Kowalski and Mulak, 2019

It is considered that ototoxicity occurs through a multifactorial mechanism, involving oxidative stress 1

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(2) efforts to develop drugs to rid neurons of amyloid plaque buildup have thus far failed to improve cognitive processing