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As a significant genetic risk factor for sporadic AD, the Apolipoprotein E (APOE4) allele demonstrates a reduced affinity for LRP1 in pericytes

Albans, VT, USA) were used to measure the locomotor activity of the experimental subjects

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Under physiological conditions, the cytoplasmic protein Kelch-like ECH-associated protein 1 (Keap1), an adapter protein of Cullin-3-based ubiquitin ligase, binds to NRF2 to suppress NRF2 activation by mediating its ubiquitination and degradation (Fig