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This period covers most of the time range, during which the WHO FCTC has been enforced (the Convention entered into force in February 2005)

The comparison of PRM quantification and isobaric tag for relative and absolute quantitation (iTRAQ) for the protein expression differences in the Treatcomparison group is shown in Figure 5 among them, 16 proteins showed consistent levels of expression changes, while two proteins showed opposite trends

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So, when e-cigarettes came along, they were marketed (and sometimes self-promoted) as the cleaner way to get nicotine