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The final stages of spinal stenosis involve severe spinal canal narrowing (75% and above) and advanced nerve compression, causing symptoms like debilitating lower back and leg pain, numbness in the lower extremities and saddle region, an inability to stand or walk, and loss of bladder or bowel control

In addition to a compatible osmolyte, proline serves as a potent scavenger of ROS and regulates the functioning of antioxidative enzymes by maintaining the NADP + / NADPH ratio

doi: 10.1073/pnas.1607571113 408 YamanoESugimotoMHirayamaAKumeSYamatoMJinGet al

Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157