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The primary outcomeweight losswas negative: the AOD-9604 treatment groups demonstrated no statistically significant reduction in body weight compared to placebo

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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In addition, pregnant women and those who are breastfeeding also require higher amounts