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For example, certain forms of smoked tobacco must be inhaled to absorb nicotine, such as cigarettes, whereas others, such as cigar and pipe tobacco, are not inhaled but nicotine is still absorbed

Model 1 As a first step, the following general linear model was used to test the association between smoking status category (that is, smokers, ex-smokers and those who have never smoked) and cortical thickness at each vertex: Cortical thickness= b 0 Intercept+ b 1 Gender+ b 2 Exact_Age_At_Scanning+ b 3 Smoking-Category+error Model 2 Next, in order to more effectively assess the doseresponse relationship between smoking and cortical thickness, the Smoking-Category term was replaced by a Pack-Years term

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