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In a 2024 pilot study, older adults with mild B12 deficiency who supplemented for three months saw significant gains in muscle strength and quality, reaching about the same level as people whose B12 was already healthy

Its stability profile, multi-pathway interactions, most robustly demonstrated through the nitric oxide and VEGF signalling systems, and broad applicability across connective tissue biology, gastrointestinal research, angiogenesis studies, neurobiology, and inflammation research make it a genuinely versatile and valuable research tool