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Patients with active RA often develop hypoproteinemia owing to high albumin consumption at the site of inflammation [139, 140]

In addition, studies also demonstrated that the C677T polymorphism of MTHFR is associated with onset age of schizophrenia in a dose-dependent manner, such as increasing numbers of the mutant T allele is linked with early onset 50

Therefore, there is an urgent need to find safe and effective alternative therapies

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