AOD-9604 and MOTS-C are two peptides that work directly on the metabolic pathways responsible for fat storage and energy regulation
Common signs include fatigue, low mood, poor concentration, muscle weakness, tingling sensations and pale skin
The evidence for dietary approaches to improving insulin sensitivity and metabolic health consistently points toward reducing refined carbohydrate and added sugar intake, increasing dietary fibre, eating regular meals with adequate protein, fibre and fat to moderate blood glucose response, and regular physical activity
For example, a musculoskeletal model might follow changes in tissue histology and movement patterns, while a gut-focused model could track barrier integrity, local signaling markers, or microbiome shifts