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Oyewole AO, Birch-Machin MA (2015) Mitochondria-targeted antioxidants

154 Nevertheless, because smoking is clearly associated with the metabolic and cardiovascular complications of hypothyroidism, as well as myriad other health problems, it is best for those with overt and subclinical hypothyroidism to avoid smoking

Future challenges to overcome in the development of NRF2 activators as disease modifying treatments include the establishment of compounds with good pharmacokinetic and pharmacodynamic profiles that ensure sustained, brain wide NRF2 activation