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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Zhang J., Jiang Y., Dong X., Meng Z., Ji L., Kang Y., Liu M., Zhou W., Song W

The higher the IC50, the greater the amount of drug required to kill cancer cells, indicating lower sensitivity to chemotherapy (42)

In HaCaT model, quercetin treatment was associated with increased expression of E-cadherin and occludin, upregulation of antioxidant enzymes including superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and catalase, and reduced levels of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), which may support improved keratinocyte migration and in vitro wound closure ( At the cytoskeletal level, keratins keratin 1 and keratin 10 (K1/K10) are critical structural proteins that contribute to the maintenance of epidermal mechanical integrity and barrier stability