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PI3K Inhibitor Reversed the Effect of Dihexa in the Brains of APP/PS1 Mice To validate whether the PI3K/AKT signaling pathway is involved in the mechanism of the Dihexa, we detected the number of neuronal cells and the level of SYP and inflammatory factors in the brains of mice after intragastric administration of wortmannin (a PI3K inhibitor)

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A 2023 study published in JCI Insight found that GLP-1 agonists reduced alcohol intake in rodents by modulating dopamine signaling in the brain's reward circuits