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The animals were kept in the Franz-Penzoldt-Zentrum (FPZ) of the University Hospital Erlangen or the animal laboratory of Med3 under standardized husbandry conditions and hygiene management in accordance with Federation of European Laboratory Animal Science Associations (FELASA)

Their flexibility makes peptides attractive drug candidates

Cardiogen Purpose: A cardiac-specific peptide supporting heart muscle function and mitochondrial repair

A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself