doi: 10.3389/ftox.2022.956885 Received 30 May 2022 Accepted 24 August 2022 Published 27 September 2022 Volume 4 - 2022 Edited by Tobias Stoeger, Helmholtz Association of German Research Centres (HZ), Germany Reviewed by Shanshan Song, University of Groningen, Netherlands Daniela Gaglio, National Research Council (CNR), Italy Updates Copyright 2022 Yang, Jannatun, Zeng, Liu, Zhang, Chen and Li
KPV Preclinical Only (Rodent Colitis Dominates) KPVs strongest preclinical signal is in rodent colitis models (DSS-induced, TNBS-induced), where KPV reduces inflammation, normalizes epithelial barrier markers, and lowers cytokine load
Short half-life of both compounds, clean GH pulses, no cortisol/prolactin noise
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