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Figure 6 The association of sarcosine and serine with clinical manifestations in LC In our investigations of metabolite levels associated with symptoms commonly seen in LC patients such as cognitive function, anxiety, chronic pain, and depression in LC patients, we conducted additional analyses

This call aims to generate robust clinical evidence and, where appropriate, data of regulatory relevance to support future regulatory interactions and subsequent clinical development

Additionally, Nrf2 , activated by oxidative stress, enhances NOS3 transcription by upregulating antioxidant response elements in the NOS3 promoter (Wu et al., 2019)