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Berberine can be taken with metformin under medical supervision, but both have overlapping glucose-lowering mechanisms that may increase the risk of hypoglycaemia and gastrointestinal side effects

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Comparative profiling of oocytes from younger versus advanced-age women has highlighted altered expression of genes involved in chromosome segregation, DNA repair, and oxidative stress response, alongside reduced expression of cohesin components (e.g., SMC1B, REC8) that maintain chromosome cohesion over time [100,101,102,103]

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