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Instead of relying on a single peptide to do everything, GLOW supports the biology of recovery through complementary mechanisms: improving the repair environment, coordinating tissue remodeling, and rebuilding structural integrity
Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism
In future work, the researchers hope to continue developing the plant-growing IGF-1 to move it to the clinic, not only for bone fracture healing but for other musculoskeletal problems as well, including osteoporosis and bone regeneration following cancer
doi: 10.1016/j.bioelechem.2021.107869 102 SzlasaWMazurekWSzewczykARembiakowskaNTunikowskaJKulbackaJ
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