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IL-10, an anti-inflammatory cytokine largely described to promote resolution of inflammation and prevent tissue damage (18), was shown to prevent such endothelial cell apoptosis (17), to preserve the expression of endothelial junction proteins, namely occludin and claudin 5 (16), and to maintain proper vascular permeability during inflammation (15)

Additionally, weight loss of up to 20% of body weight has been reported, making it one of the most effective pharmacological options for obesity management

HOMA2-IR returns in proportion to regain (about +0.6% at under-25% regain to +39.5% at 50-75%)

NIH Office of Dietary Supplements