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Cellular senescence in cancer: clinical detection and prognostic implications

DOX was administered intraperitoneally using a three-injection protocol: two injections on day 1 at 10:00 AM and 5:00 PM and one injection on day 2 at 10:00 AM at a dose of 2.65 mg/kg per injection, totaling 7.95 mg/kg

Promotes new cartilage cell growth while reducing inflammatory breakdown

For example, SASP reduces GSH expression levels at the cellular level, which induces growth arrest in breast cancer cells and increase the efficacy of anticancer drugs, such as doxorubicin (83), similar to preclinical investigations in vitro and in vivo (84)