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however, because of the relatively small number of patients treated, the lack of long-term follow-up data on large numbers of patients, and the potential for serious AEs (e.g., immunosuppression, nephrotoxicity), the Panel judged some uncertainty remains in the balance between benefits and risks/burdens

"The islet's bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies"

That roughly 3:1 ratio of fat loss to lean loss is better than what most pharmacological interventions achieve, though the lean mass reduction remains a concern that some practitioners hope to mitigate through peptide strategies combining weight loss and muscle preservation

Drmic, S