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4.4 Neuroinflammation The neurotoxic environment created by synthetic cathinones activates microglia and astrocytes, leading to the release of proinflammatory cytokines, such as IL-1 and TNF-

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Additionally, the PI3K-Akt pathway is often synergistically activated, modulating cell survival, metabolism, and inflammatory signaling during the immune response 145

You have little or no improvement by the expected checkpoint: A follow-up is appropriate if core symptoms remain largely unchanged after a fair trial