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Nature 497 , 633637 (2013)

Although less than 1% of bacteria in the healthy gut contain genes for trimethylamine (TMA) synthesis, this is sufficient to regulate the balance of choline metabolism, indicating that these trace intestinal microorganisms and choline are essential for host health (Rath et al., 2017)

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition