The combination of the N-terminal amine, the histidine imidazole, and the intervening amide nitrogen is a recurrent high-affinity copper-binding motif in peptide biochemistry it appears in human serum albumin's N-terminal copper-binding site, in various other copper-binding peptides, and in synthetic copper-binding peptide design
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On the other hand, the adrenal cortex synthesizes and releases cortisol, which increases gluconeogenesis and insulin resistance to ensure energy production and also plays an essential role in modulating inflammation during the acute phase [104,110]
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