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2012;7:e48872

The two major homocysteine-utilizing enzymes, methionine synthase and cystathionine -synthase, show reciprocal sensitivity to oxidative conditions (Mosharov et al., 2000)

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In addition to neural connections, the central clock system also synchronizes the circadian rhythms of the peripheral clock system through hormones or factors, such as arginine vasopressin (AVP) and tumor necrosis factor (TNF) ( FIGURE 1 The clock system mainly regulates metabolism in the following three ways