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Karanasiou, A., Alastuey, A, Amato, F., Renzi, M, Stafoggia, M., Tobias, A., Reche, C., Forastiere, F., Gumy, S., Mudu, P

Cannabinol for acute treatment of insomnia disorder in a randomized placebo-controlled crossover trial

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When nicotine stimulates those nerves, a few reactions can occur: The diaphragm becomes briefly irritated and spasms Nicotine may stimulate stomach acid production, which can irritate nearby nerves Swallowing increases, sometimes trapping air in the stomach The body responds to the effects of nicotine by activating reflexes tied to breathing Public health groups tied to disease control often point out that nicotine affects several systems at once