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Their impact in the disease initiation and progression needs further investigation in vivo , but in general, these modifications in mutant ATXN3 were shown to modulate its stability, subcellular localization, enzymatic activity, neuroprotective function, self-assembly, its interaction affinity with molecular partners, and/or pathogenicity

Rafnsson S, Saravanan P, Bhopal R, Yajnik C

Structured Illumination Microscopy was performed using a Zeiss Elyra PS1 microscope using a 63 1.4 (n.a.) plan apo chromate oil immersion lens and 5 phases and 5 rotations of the illumination pattern

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